The intellectual and physical development of children with CDC-syndrome is extremly variable. In older documents a far more negativ picture of the development is drawn as it really shows today. There seem to be reasons for this:

· insufficient statistical recording ( mildly affected cases not always recognized as CDC)
· cases almost exclusively outside the family (institutions)
· no or insufficient early intervention programs

In the recent years a growing number of CDC cases have been identified who are only mildly affected:

· less distinctive cry which often disappears in the childhood
· less physical problems

Some even meet the "milestones of development" within the standard time and walk at 1 -2 years of age. These mildly affected children learn to speak very well but nevertheless still need speech therapy. In quite unusual cases they even can learn to read and to write.
The following table compares the milestones of the average development of CDC children with the typical normal development:

Time in Months

 Developmental Milestone

 Normal Development

 Children with CDC




Grasp objects


Roll over


Pull to stand


Reach objects




Sit alone


Transfer objects




Discover surrounding


Say 1st word


Understand directions


Walk alone


Toilet trained


Dress self



A small percentage of children with CDC don't walk , don't speak and some have serious medical problems with a reduced life-span. However it seems that the majority, despite a number of persistent minor health problems, thrive and live well into adulthood.
They generally walk between 2 and 6 years of age and partly speak well enough that the family and other familiar persons understand most of their communication.

At birth nobody can determine how much a child will be affected by CDC.

In general children and adults with the CDC syndrome are kind and happy people.

They enjoy participating in social life (strolling through town etc.)

However, the best course of action for carers is the optimization of the childs developmental potential:

· start as early as possible with an early intervention program !
· enable as much as possible a normal live !